Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Iloperidone hydrochloride1299470-39-5HY-17410A462.94C24H28ClFN2O4>98%Solubility:DMSOMechanisms: Pathways:GPCR/G protein; Target:Dopamine Receptor Pathways:Neuronal Signaling; Target:Dopamine Receptor Pathways:GPCR/G protein; Target:5-HT Receptor Pathways:Neuronal Signaling; Target:5-HT Receptor Biological Activity:BiologicalActivity:Iloperidone (hydrochloride) is a D(2)/5-HT(2) receptor antagonistis, which is an atypical antipsychoticfor the treatment of schizophrenia symptoms. Target: 5-HT receptor; Dopamine receptor Iloperidone (hydrochloride) is the hydrochloride of iloperidone, iloperidone (HP 873; 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy] -3- methoxyphenyl]ethanone) is a compoundcurrently in clinical trials for the treatment of schizophrenia. Iloperidone displays affinity for dopamineD2 receptors and for 5-HT2A receptors and has a variety of in vivo activities suggestive of anatypicalantipsychoticIloperidonedisplayedhigheraffinityforthedopamineD3receptor(Ki=71atypical antipsychotic. Iloperidone displayed higher affinity for the dopamine D3 receptor (Ki = 7.1nM) than for the dopamine D4 receptor (Ki = 25 nM). Iloperidone displayed high affinity for the 5-HT6 and 5-HT7 receptors (Ki = 42.7 and 21.6 nM, respectively), and was found to have higher af...References:[1]. Kongsamut, S., et al., Iloperidone binding to human and rat dopamine and 5-HT receptors. Eur JPharmacol, 1996. 317(2-3): p. 417-23.()[2]. Sainati, S.M., et al., Safety, tolerability, and effect of food on the pharmacokinetics of iloperidone(HP 873), a potential atypical antipsychotic. J Clin Pharmacol, 1995. 35(7): p. 713-20. [3]. Albers, L.J., A. Musenga, and M.A. Raggi, Iloperidone: a new benzisoxazole atypicalantipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market? ExpertOpin Investig Drugs, 2008. 17(1): p. 61-75. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com
