Peptides, Inhibitors, Agonists
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Product Data Sheet
Product Name:Cat. No.:
Pentiapine (CGS 10746)GC33730
Chemical Properties
Cas No.ChemicalNameCanonicalSMILESFormulaSolubilityGeneral tipsShippingCondition
81382-51-6N/A
CN1CCN(C2=NC3=CC=CC=C3SC4=NC=CN42)CC1C15H17N5SSoluble in DMSO
M.WtStorage
299.39Store at -20°C
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bathfor a while.Stock solution can be stored below -20℃ for several months.
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice uponrequest.
Structure
Background
Pentiapine is a novel dopamine release inhibitor.
Caution: Producthasnot been fully validated for medical applications. For research use only.
Tel: (626) 353-8530 Fax: (626) 353-8530 E-mail: tech@glpbio.com
Address: 10292 Central Ave. #205, Montclair, CA, USA
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Peptides, Inhibitors, Agonists
www.glpbio.com
Product Data Sheet
Pentiapine is a novel dopamine release inhibitor.The results show that Pentiapine dose-dependently reduces motoractivity of mice. Moreover, Pentiapine dose-dependently reduces morphine-induced hyperactivity. Newman-Keulspost-hoc comparisons indicate that the group receiving morphine plus saline presents more activity than the groupsreceiving morphine plus 2 (P<0.05), 4, 8, 16, 24 and 32 (P<0.01) mg/kg of Pentiapine. Moreover, the groups
receiving morphine plus 0.5, 1 and 2 mg/kg of Pentiapine present more activity than the groups receiving morphineplus 4, 8, 16, 24 and 32 mg/kg of Pentiapine (P<0.01)[1]. 30 mg/kg dose of Pentiapine completely blocks the
methylenedioxymethamphetamine (MDMA) conditioned place preference (CPP) and also blocks the establishment ofa cocaine CPP[2].
[1]. Manzanedo C, et al. Effects of CGS 10746B on hyperactivity and place preference induced by morphine. BehavBrain Res. 2001 Nov 29;126(1-2):23-32. [2]. Bilsky EJ, et al. CGS 10746B, a novel dopamine release inhibitor, blocksthe establishment of cocaine and MDMA conditioned place preferences. Pharmacol Biochem Behav. 1998Jan;59(1):215-20.
Caution: Producthasnot been fully validated for medical applications. For research use only.
Tel: (626) 353-8530 Fax: (626) 353-8530 E-mail: tech@glpbio.com
Address: 10292 Central Ave. #205, Montclair, CA, USA
2www.glpbio.com
